Quick answer
- Winner
- San Francisco 49ers
- Final score
- San Francisco 49ers 41–22 Arizona Cardinals
- Halftime
- San Francisco 49ers 25–10 Arizona Cardinals at halftime
- FantasyHQ MVP
- Mi. Wilson
- Top passer
- Jacoby Brissett
- Biggest EPA play
- (4:44) (Shotgun) 7-J.Brissett pass short right intended for 84-E.Higgins INTERCEPTED by 2-…
- Game date
- 2025-11-16
Game summary
The San Francisco 49ers beat the Arizona Cardinals 41–22 on 2025-11-16. Mi. Wilson posted a game-high +9.73 total EPA in the receiving.
The highest-scoring period was Q1 with 20 combined points.
Line score
Final score and points by quarter.
| Q1 | Q2 | Q3 | Q4 | — | T | |
|---|---|---|---|---|---|---|
 San Francisco 49ers | 13 | 12 | 10 | 6 | 0 | 41 |
 Arizona Cardinals | 7 | 3 | 0 | 12 | 0 | 22 |
Scoring Map
Each pin marks where a score occurred on the field — yard line from play-by-play.
SFSan Francisco 49ers
(14:47) 23-C.McCaffrey right guard for 1 yard, TOUCHDOWN.
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
(9:57) (Shotgun) 13-B.Purdy pass deep right to 85-G.Kittle for 30 yards, TOUCHDOWN [97-W.Nolen].
(5:03) 78-J.Fryar reported in as eligible. 20-Z.Knight left tackle for 6 yards, TOUCHDOWN.
38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell.
(13:44) 13-B.Purdy pass short left to 23-C.McCaffrey for 9 yards, TOUCHDOWN.
(6:34) 38-C.Ryland 26 yard field goal is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell.
(1:06) 18-E.Pineiro 48 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
(:00) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
(7:32) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
(2:37) (Shotgun) 13-B.Purdy pass short left to 85-G.Kittle for 4 yards, TOUCHDOWN.
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
(8:32) (No Huddle, Shotgun) 7-J.Brissett pass short middle to 85-T.McBride for 10 yards, TOUCHDOWN.
(4:49) 23-C.McCaffrey right end for 4 yards, TOUCHDOWN.
(2:48) (No Huddle, Shotgun) 7-J.Brissett pass deep left to 4-G.Dortch for 17 yards, TOUCHDOWN.
ARIArizona CardinalsFantasyHQ Analytics
Scoring timeline
Chronological scoring plays — scroll to follow the game.
- SFSan Francisco 49ers
Q1 14:47TD Christian McCaffreyPoints+6
- Yard line
- ARI 1
- Score
- 6-0
(14:47) 23-C.McCaffrey right guard for 1 yard, TOUCHDOWN.
- SFSan Francisco 49ers
Q1 14:44XP Eddy PineiroPoints+1
- Yard line
- ARI 15
- Score
- 7-0
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
- SFSan Francisco 49ers
Q1 9:57TD George KittlePoints+6
- Yard line
- ARI 30
- Score
- 13-0
(9:57) (Shotgun) 13-B.Purdy pass deep right to 85-G.Kittle for 30 yards, TOUCHDOWN [97-W.Nolen].
- ARIArizona Cardinals
Q1 5:03TD ZKZ. KnightPoints+6
- Yard line
- SF 6
- Score
- 13-6
(5:03) 78-J.Fryar reported in as eligible. 20-Z.Knight left tackle for 6 yards, TOUCHDOWN.
- ARIArizona Cardinals
Q1 4:58XP Chad RylandPoints+1
- Yard line
- SF 15
- Score
- 13-7
38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell.
- SFSan Francisco 49ers
Q2 13:44TD Christian McCaffreyPoints+6
- Yard line
- ARI 9
- Score
- 19-7
(13:44) 13-B.Purdy pass short left to 23-C.McCaffrey for 9 yards, TOUCHDOWN.
- ARIArizona Cardinals
Q2 6:34FG Chad RylandPoints+3
- Yard line
- SF 8
- Score
- 19-10
(6:34) 38-C.Ryland 26 yard field goal is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell.
- SFSan Francisco 49ers
Q2 1:06FG Eddy PineiroPoints+3
- Yard line
- ARI 30
- Score
- 22-10
(1:06) 18-E.Pineiro 48 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
- SFSan Francisco 49ers
Q2 0:00FG Eddy PineiroPoints+3
- Yard line
- ARI 29
- Score
- 25-10
(:00) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
- SFSan Francisco 49ers
Q3 7:32FG Eddy PineiroPoints+3
- Yard line
- ARI 29
- Score
- 28-10
(7:32) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
- SFSan Francisco 49ers
Q3 2:37TD George KittlePoints+6
- Yard line
- ARI 4
- Score
- 34-10
(2:37) (Shotgun) 13-B.Purdy pass short left to 85-G.Kittle for 4 yards, TOUCHDOWN.
- SFSan Francisco 49ers
Q3 2:32XP Eddy PineiroPoints+1
- Yard line
- ARI 15
- Score
- 35-10
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
- ARIArizona Cardinals
Q4 8:32TD Trey McBridePoints+6
- Yard line
- SF 10
- Score
- 35-16
(8:32) (No Huddle, Shotgun) 7-J.Brissett pass short middle to 85-T.McBride for 10 yards, TOUCHDOWN.
- SFSan Francisco 49ers
Q4 4:49TD Christian McCaffreyPoints+6
- Yard line
- ARI 4
- Score
- 41-16
(4:49) 23-C.McCaffrey right end for 4 yards, TOUCHDOWN.
- ARIArizona Cardinals
Q4 2:48TD Greg DortchPoints+6
- Yard line
- SF 17
- Score
- 41-22
(2:48) (No Huddle, Shotgun) 7-J.Brissett pass deep left to 4-G.Dortch for 17 yards, TOUCHDOWN.
Stars of the game
Top performers by total expected points added (EPA).
- 1Mi. Wilson · Arizona Cardinals · Receiving · +9.73 total EPA · 18 snaps · +0.54 EPA/play
- 2
Brock Purdy · San Francisco 49ers · Passing · +9.06 total EPA · 30 snaps · +0.30 EPA/play - 3George Kittle · San Francisco 49ers · Receiving · +8.51 total EPA · 6 snaps · +1.42 EPA/play
- 4Greg Dortch · Arizona Cardinals · Receiving · +7.86 total EPA · 6 snaps · +1.31 EPA/play
- 5Trey McBride · Arizona Cardinals · Receiving · +5.90 total EPA · 12 snaps · +0.49 EPA/play
- 6Christian McCaffrey · San Francisco 49ers · Rushing · +4.43 total EPA · 13 snaps · +0.34 EPA/play
- 7
Jacoby Brissett · Arizona Cardinals · Passing · +4.02 total EPA · 60 snaps · +0.07 EPA/play - 8Christian McCaffrey · San Francisco 49ers · Receiving · +3.49 total EPA · 6 snaps · +0.58 EPA/play
FantasyHQ Game MVP
Highest total EPA with the player's top snap and the game's biggest single play when different.
FantasyHQ Game MVP
Mi. Wilson — ARI · Receiving
Mi. Wilson posted the highest total EPA (+9.73) in the game, the strongest overall impact for Arizona Cardinals. Across 18 counted snaps, they averaged +0.54 EPA per play.
Mi. Wilson's top snap (+3.10 EPA): (8:21) (Shotgun) 7-J.Brissett pass deep left to 14-Mi.Wilson to SF 31 for 34 yards (20-U.Stout) [93-K.Davis]. Penalty on SF-20-U.Stout, Defensive Pass Interference, declined.
Biggest single play (-9.21 EPA): Jacoby Brissett — (4:44) (Shotgun) 7-J.Brissett pass short right intended for 84-E.Higgins INTERCEPTED by 2-D.Lenoir [91-S.Okuayinonu] at SF 22. 2-D.Lenoir to ARI 14 for 64 yards (22-M.Carter).
Quarterback report card
Jacoby Brissett led all passers in efficiency for Arizona Cardinals, setting the tone in the passing game according to FantasyHQ analytics.
- Jacoby Brissett (Arizona Cardinals) · 60 dropbacks · 78.3% completion · +12.4% CPOE · +0.07 EPA/play · +4.02 total EPA
- Brock Purdy (San Francisco 49ers) · 30 dropbacks · 63.3% completion · +10.1% CPOE · +0.30 EPA/play · +9.06 total EPA
Team stats comparison
Side-by-side offensive and defensive efficiency.
| Stat | San Francisco 49ers | Arizona Cardinals |
|---|---|---|
| Offensive EPA/play | +0.250 | -0.067 |
| Offensive success rate | 56.2% | 46.4% |
| Pass EPA/play | +0.302 | +0.067 |
| Rush EPA/play | +0.042 | -0.314 |
| Defensive EPA/play | +0.067 | -0.250 |
| Defensive success rate | 53.6% | 43.8% |
Drive & efficiency notes
Despite the final score, San Francisco 49ers generated the better offensive EPA per play (+0.25 vs -0.07), suggesting they moved the ball more efficiently.
Season benchmark context (offensive EPA per play):
- San Francisco 49ers: +0.25 EPA/play (93rd percentile vs. 2025 team-game averages)
- Arizona Cardinals: -0.07 EPA/play (31st percentile vs. 2025 team-game averages)
- Arizona Cardinals: 11 drives, -6.55 total EPA, 4 scoring drives
- San Francisco 49ers: 12 drives, +18.23 total EPA, 8 scoring drives
Who scored touchdowns and field goals
Every touchdown and field goal from official play-by-play.
Touchdowns
- San Francisco 49ers — Christian McCaffrey
- San Francisco 49ers — George Kittle (Brock Purdy pass)
- Arizona Cardinals — Z. Knight
- San Francisco 49ers — Christian McCaffrey (Brock Purdy pass)
- San Francisco 49ers — George Kittle (Brock Purdy pass)
- Arizona Cardinals — Trey McBride (Jacoby Brissett pass)
- San Francisco 49ers — Christian McCaffrey
- Arizona Cardinals — Greg Dortch (Jacoby Brissett pass)
Field goals
- Arizona Cardinals — Chad Ryland
- San Francisco 49ers — Eddy Pineiro
- San Francisco 49ers — Eddy Pineiro
- San Francisco 49ers — Eddy Pineiro
Quarter by quarter
Quarter-by-quarter recap from live scoring plays.
The opening quarter: San Francisco 49ers won the period 13–7. San Francisco 49ers found the end zone from the ARI 1 (Q1 14:47) — (14:47) 23-C.McCaffrey right guard for 1 yard, TOUCHDOWN.; San Francisco 49ers added 1 points from the ARI 15 (Q1 14:44) — 18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers found the end zone from the ARI 30 (Q1 9:57) — (9:57) (Shotgun) 13-B.Purdy pass deep right to 85-G.Kittle for 30 yards, TOUCHDOWN [97-W.Nolen].; Arizona Cardinals found the end zone from the SF 6 (Q1 5:03) — (5:03) 78-J.Fryar reported in as eligible. 20-Z.Knight left tackle for 6 yards, TOUCHDOWN.; Arizona Cardinals added 1 points from the SF 15 (Q1 4:58) — 38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell..
The second quarter: San Francisco 49ers won the period 12–3. San Francisco 49ers found the end zone from the ARI 9 (Q2 13:44) — (13:44) 13-B.Purdy pass short left to 23-C.McCaffrey for 9 yards, TOUCHDOWN.; Arizona Cardinals connected on a field goal from the SF 8 (Q2 6:34) — (6:34) 38-C.Ryland 26 yard field goal is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell.; San Francisco 49ers connected on a field goal from the ARI 30 (Q2 1:06) — (1:06) 18-E.Pineiro 48 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers connected on a field goal from the ARI 29 (Q2 0:00) — (:00) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead..
The third quarter: San Francisco 49ers won the period 10–0. San Francisco 49ers connected on a field goal from the ARI 29 (Q3 7:32) — (7:32) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers found the end zone from the ARI 4 (Q3 2:37) — (2:37) (Shotgun) 13-B.Purdy pass short left to 85-G.Kittle for 4 yards, TOUCHDOWN.; San Francisco 49ers added 1 points from the ARI 15 (Q3 2:32) — 18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead..
The fourth quarter: Arizona Cardinals won the period 12–6. Arizona Cardinals found the end zone from the SF 10 (Q4 8:32) — (8:32) (No Huddle, Shotgun) 7-J.Brissett pass short middle to 85-T.McBride for 10 yards, TOUCHDOWN.; San Francisco 49ers found the end zone from the ARI 4 (Q4 4:49) — (4:49) 23-C.McCaffrey right end for 4 yards, TOUCHDOWN.; Arizona Cardinals found the end zone from the SF 17 (Q4 2:48) — (2:48) (No Huddle, Shotgun) 7-J.Brissett pass deep left to 4-G.Dortch for 17 yards, TOUCHDOWN..
Turning points
Plays that moved win probability the most.
- San Francisco 49ers (Q1 15:00) — 38-C.Ryland kicks 64 yards from ARI 35 to SF 1. 9-S.Moore to ARI 1 for 98 yards (13-K.Clark).
- San Francisco 49ers (Q1 3:03) — (3:03) 7-T.Morstead punts 49 yards to ARI 16, Center-46-J.Weeks. 4-G.Dortch to SF 44 for 40 yards (59-C.Robinson; 46-J.Weeks).
- Arizona Cardinals (Q1 14:38) — (14:38) 78-J.Fryar reported in as eligible. 20-Z.Knight right tackle to ARI 34 for 7 yards (2-D.Lenoir; 6-M.Mustapha).
- Arizona Cardinals (Q1 1:00) — (1:00) 38-C.Ryland 58 yard field goal is No Good, Wide Left, Center-46-A.Brewer, Holder-39-P.O'Donnell.
- San Francisco 49ers (Q1 11:19) — (11:19) (Shotgun) 13-B.Purdy pass deep left to 15-J.Jennings to ARI 43 for 25 yards (3-B.Baker).
Impact plays
Highest EPA snaps that flipped field position.
- Arizona Cardinals (Q3 4:44) — (4:44) (Shotgun) 7-J.Brissett pass short right intended for 84-E.Higgins INTERCEPTED by 2-D.Lenoir [91-S.Okuayinonu] at SF 22. 2-D.Lenoir to ARI 14 for 64 yards (22-M.Carter).
- San Francisco 49ers (Q1 15:00) — 38-C.Ryland kicks 64 yards from ARI 35 to SF 1. 9-S.Moore to ARI 1 for 98 yards (13-K.Clark).
- Arizona Cardinals (Q4 14:03) — (14:03) (Shotgun) 7-J.Brissett pass short middle to 84-E.Higgins to SF 1 for 7 yards (20-U.Stout; 59-C.Robinson). FUMBLES (20-U.Stout), RECOVERED by SF-56-K.White at SF 3. 56-K.White to SF 3 for no ga
- Arizona Cardinals (Q1 8:21) — (8:21) (Shotgun) 7-J.Brissett pass deep left to 14-Mi.Wilson to SF 31 for 34 yards (20-U.Stout) [93-K.Davis]. Penalty on SF-20-U.Stout, Defensive Pass Interference, declined.
Every scoring play
Chronological scoring with play-by-play context.
- San Francisco 49ers TD (+6) — Q1 14:47 · ARI 1 · Score 6-0
(14:47) 23-C.McCaffrey right guard for 1 yard, TOUCHDOWN. - San Francisco 49ers XP (+1) — Q1 14:44 · ARI 15 · Score 7-0
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. - San Francisco 49ers TD (+6) — Q1 9:57 · ARI 30 · Score 13-0
(9:57) (Shotgun) 13-B.Purdy pass deep right to 85-G.Kittle for 30 yards, TOUCHDOWN [97-W.Nolen]. - Arizona Cardinals TD (+6) — Q1 5:03 · SF 6 · Score 13-6
(5:03) 78-J.Fryar reported in as eligible. 20-Z.Knight left tackle for 6 yards, TOUCHDOWN. - Arizona Cardinals XP (+1) — Q1 4:58 · SF 15 · Score 13-7
38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell. - San Francisco 49ers TD (+6) — Q2 13:44 · ARI 9 · Score 19-7
(13:44) 13-B.Purdy pass short left to 23-C.McCaffrey for 9 yards, TOUCHDOWN. - Arizona Cardinals FG (+3) — Q2 6:34 · SF 8 · Score 19-10
(6:34) 38-C.Ryland 26 yard field goal is GOOD, Center-46-A.Brewer, Holder-39-P.O'Donnell. - San Francisco 49ers FG (+3) — Q2 1:06 · ARI 30 · Score 22-10
(1:06) 18-E.Pineiro 48 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. - San Francisco 49ers FG (+3) — Q2 0:00 · ARI 29 · Score 25-10
(:00) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. - San Francisco 49ers FG (+3) — Q3 7:32 · ARI 29 · Score 28-10
(7:32) 18-E.Pineiro 47 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. - San Francisco 49ers TD (+6) — Q3 2:37 · ARI 4 · Score 34-10
(2:37) (Shotgun) 13-B.Purdy pass short left to 85-G.Kittle for 4 yards, TOUCHDOWN. - San Francisco 49ers XP (+1) — Q3 2:32 · ARI 15 · Score 35-10
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. - Arizona Cardinals TD (+6) — Q4 8:32 · SF 10 · Score 35-16
(8:32) (No Huddle, Shotgun) 7-J.Brissett pass short middle to 85-T.McBride for 10 yards, TOUCHDOWN. - San Francisco 49ers TD (+6) — Q4 4:49 · ARI 4 · Score 41-16
(4:49) 23-C.McCaffrey right end for 4 yards, TOUCHDOWN. - Arizona Cardinals TD (+6) — Q4 2:48 · SF 17 · Score 41-22
(2:48) (No Huddle, Shotgun) 7-J.Brissett pass deep left to 4-G.Dortch for 17 yards, TOUCHDOWN.
Key takeaways
What to remember for fantasy research and follow-up box score digging.
- San Francisco 49ers earned the result — use the box score for snap-level context.
- Mi. Wilson (Arizona Cardinals) led total EPA — start here for highlight and prop research.
- Jacoby Brissett (ARI) finished above expected through the air (positive CPOE).
- Brock Purdy (SF) finished above expected through the air (positive CPOE).
Frequently asked questions
Who won San Francisco 49ers vs Arizona Cardinals on 2025-11-16?
The San Francisco 49ers beat the Arizona Cardinals 41-22 in Week 11, 2025.
What was the score by quarter in San Francisco 49ers vs Arizona Cardinals?
Q1: San Francisco 49ers 13, Arizona Cardinals 7; Q2: San Francisco 49ers 12, Arizona Cardinals 3; Q3: San Francisco 49ers 10, Arizona Cardinals 0; Q4: San Francisco 49ers 6, Arizona Cardinals 12; Final: San Francisco 49ers 41, Arizona Cardinals 22.
Who scored touchdowns and field goals in San Francisco 49ers vs Arizona Cardinals?
San Francisco 49ers touchdown — C. McCaffrey (Q1 14:47) San Francisco 49ers touchdown — G. Kittle (B. Purdy pass) (Q1 9:57) Arizona Cardinals touchdown — Z. Knight (Q1 5:03) San Francisco 49ers touchdown — C. McCaffrey (B. Purdy pass) (Q2 13:44) San Francisco 49ers touchdown — G. Kittle (B. Purdy pass) (Q3 2:37) Arizona Cardinals touchdown — T. McBride (J. Brissett pass) (Q4 8:32) San Francisco 49ers touchdown — C. McCaffrey (Q4 4:49) Arizona Cardinals touchdown — G. Dortch (J. Brissett pass) (Q4 2:48) Arizona Cardinals field goal — C. Ryland (Q2 6:34, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q2 1:06, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q2 0:00, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q3 7:32, 3 pts) Extra points followed each touchdown unless noted in the play-by-play.
How did the quarterbacks play in San Francisco 49ers vs Arizona Cardinals?
Jacoby Brissett (Arizona Cardinals), 78.3% completion, +12.4% CPOE, +0.07 EPA per dropback, +4.02 total passing EPA. Brock Purdy (San Francisco 49ers), 63.3% completion, +10.1% CPOE, +0.30 EPA per dropback, +9.06 total passing EPA.
Who was FantasyHQ's player of the game in San Francisco 49ers vs Arizona Cardinals?
Mi. Wilson (Arizona Cardinals) was FantasyHQ's Game MVP with +9.73 total EPA on Receiving plays. across 18 snaps. Their top snap (+3.10 EPA): (8:21) (Shotgun) 7-J.Brissett pass deep left to 14-Mi.Wilson to SF 31 for 34 yards (20-U.Stout) [93-K.Davis]. Penalty on SF-20-U.Stout, Defensive Pass Interference, declined..
Season records after this game
San Francisco 49ers
Entered 6-4 Now 7-4 W
Arizona Cardinals
Entered 3-6 Now 3-7 L
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