LOUISVILLE CARDINALS
LOU
8-5
30% win
Final
16 – 31
CLEMSON TIGERS
CLEM
11-3
70% win
Win probability
SP+ model
LOU 30%
CLEM 70%
Pick: CLEM
CLEM -3.1
O/U 56.0
- Record
- 8-5
- SP+
-
+9.0
- SP+ Off
- 27.0
- SP+ Def
- -19.1
Clemson Tigers
ACC
- Record
- 11-3
- SP+
-
+17.6
- SP+ Off
- 34.9
- SP+ Def
- -18.5
Recent head-to-head
LOU 1–7 CLEM
2025
Wk 12
Wk 12
CLEM
W
20
FINAL
19
LOU
2024
Wk 10
Wk 10
LOU
W
33
FINAL
21
CLEM
2021
Wk 10
Wk 10
CLEM
W
30
FINAL
24
LOU
2019
Wk 8
Wk 8
CLEM
W
45
FINAL
10
LOU
2018
Wk 10
Wk 10
LOU
16
FINAL
77
W
CLEM
2017
Wk 3
Wk 3
CLEM
W
47
FINAL
21
LOU
2016
Wk 5
Wk 5
LOU
36
FINAL
42
W
CLEM
2015
Wk 3
Wk 3
CLEM
W
20
FINAL
17
LOU
Recent form
Louisville Cardinals
vs UK
@ SMU
vs CAL
@ VT
Clemson Tigers
@ SC
vs FUR
vs FSU
vs DUKE
Cardinals vs Tigers — FAQ
Who wins Cardinals vs Tigers?
FantasyHQ's SP+ model projects Clemson at 70% to win (24.9–31.1) for 2022 CFB Week 11.
What is the Cardinals vs Tigers predicted score?
Projected score: LOU 24.9 – CLEM 31.1. Spread model: CLEM -3.1; total: O/U 56.0.
When is the Cardinals vs Tigers game?
Louisville Cardinals face Clemson Tigers in 2022 CFB Week 11 on Sat, Nov 12 at 3:30 PM ET. Venue: Memorial Stadium (Clemson, SC).