CLEMSON TIGERS
CLEM
10-3
69% win
Final
30 – 24
LOUISVILLE CARDINALS
LOU
6-7
31% win
Win probability
SP+ model
CLEM 69%
LOU 31%
Pick: CLEM
CLEM -2.2
O/U 56.0
Clemson Tigers
ACC
- Record
- 10-3
- SP+
-
+18.7
- SP+ Off
- 28.3
- SP+ Def
- -11.6
- Record
- 6-7
- SP+
-
+7.8
- SP+ Off
- 34.9
- SP+ Def
- -26.6
Recent head-to-head
CLEM 7–1 LOU
2025
Wk 12
Wk 12
CLEM
W
20
FINAL
19
LOU
2024
Wk 10
Wk 10
LOU
W
33
FINAL
21
CLEM
2022
Wk 11
Wk 11
LOU
16
FINAL
31
W
CLEM
2019
Wk 8
Wk 8
CLEM
W
45
FINAL
10
LOU
2018
Wk 10
Wk 10
LOU
16
FINAL
77
W
CLEM
2017
Wk 3
Wk 3
CLEM
W
47
FINAL
21
LOU
2016
Wk 5
Wk 5
LOU
36
FINAL
42
W
CLEM
2015
Wk 3
Wk 3
CLEM
W
20
FINAL
17
LOU
Recent form
Clemson Tigers
@ SC
vs FUR
vs FSU
vs DUKE
Louisville Cardinals
vs UK
@ SMU
vs CAL
@ VT
Tigers vs Cardinals — FAQ
Who wins Tigers vs Cardinals?
FantasyHQ's SP+ model projects Clemson at 69% to win (30.2–25.8) for 2021 CFB Week 10.
What is the Tigers vs Cardinals predicted score?
Projected score: CLEM 30.2 – LOU 25.8. Spread model: CLEM -2.2; total: O/U 56.0.
When is the Tigers vs Cardinals game?
Clemson Tigers face Louisville Cardinals in 2021 CFB Week 10 on Sat, Nov 6 at 7:30 PM ET. Venue: L&N Federal Credit Union Stadium.