Cardinals 15–16 49ers: Score, Stats & Recap | Week 3, 2025

Q: How did the quarterbacks play in Arizona Cardinals vs San Francisco 49ers?

M. Jones (San Francisco 49ers), 61.4% completion, +3.3% CPOE, -0.02 EPA per dropback, -0.84 total passing EPA. K. Murray (Arizona Cardinals), 53.7% completion, -2.6% CPOE, +0.15 EPA per dropback, +5.96 total passing EPA.

Q: Who was FantasyHQ's player of the game in Arizona Cardinals vs San Francisco 49ers?

K. Murray (Arizona Cardinals) was FantasyHQ's Game MVP with +5.96 total EPA on Passing plays. across 41 snaps. Their top snap (+3.69 EPA): (9:29) (Shotgun) 1-K.Murray pass incomplete deep left to 18-M.Harrison. PENALTY on SF-0-R.Green, Defensive Pass Interference, 33 yards, enforced at SF 34 - No Play..

Quick answer

Winner: San Francisco 49ers
Final score: San Francisco 49ers 16–15 Arizona Cardinals
Halftime: Arizona Cardinals 3–9 San Francisco 49ers at halftime
FantasyHQ MVP: Kenneth Murray, Jr.
Top passer: Marcus Jones
Biggest EPA play: (12:06) (Shotgun) 10-M.Jones pass deep right to 1-R.Pearsall pushed ob at ARI 6 for 34 yar…
Game date: 2025-09-21

Game summary

The San Francisco 49ers beat the Arizona Cardinals 16–15 on 2025-09-21. Kenneth Murray, Jr. posted a game-high +5.96 total EPA in the passing.

The highest-scoring period was Q4 with 22 combined points.

Line score

Final score and points by quarter.

	Q2	Q3	Q4	—	—	T
Arizona Cardinals	3	3	9	0	0	15
San Francisco 49ers	9	0	13	0	0	16

Scoring Map

Each pin marks where a score occurred on the field — yard line from play-by-play.

ARIArizona Cardinals

+3SF 16

+3ARI 33

+3SF 35

ARI 1

+1SF 15

SFSan Francisco 49ers

FantasyHQ Analytics

Scoring timeline

12 scores

Chronological scoring plays — scroll to follow the game.

ARIArizona Cardinals
Q2 8:48FG
Chad Ryland
Points+3
Yard line
SF 16
Score
3-0
(8:48) 38-C.Ryland 34 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
SFSan Francisco 49ers
Q2 4:26FG
Eddy Pineiro
Points+3
Yard line
ARI 19
Score
3-3
(4:26) 18-E.Pineiro 38 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
SFSan Francisco 49ers
Q2 0:20FG
Eddy Pineiro
Points+3
Yard line
ARI 33
Score
3-6
(:20) 18-E.Pineiro 51 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
SFSan Francisco 49ers
Q2 0:17FG
Eddy Pineiro
Points+3
Yard line
SF 35
Score
3-6
18-E.Pineiro kicks 61 yards from SF 35 to ARI 4. 4-G.Dortch to ARI 37 for 33 yards (27-J.Brown).
ARIArizona Cardinals
Q3 6:40FG
Chad Ryland
Points+3
Yard line
SF 9
Score
6-6
(6:40) 38-C.Ryland 28 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
SFSan Francisco 49ers
Q4 10:54TD
Kyle Juszczyk
Points+6
Yard line
ARI 1
Score
6-12
(10:54) 10-M.Jones pass short left to 44-K.Juszczyk for 1 yard, TOUCHDOWN [5-B.Browning].
SFSan Francisco 49ers
Q4 10:50XP
Eddy Pineiro
Points+1
Yard line
ARI 15
Score
6-13
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
ARIArizona Cardinals
Q4 8:42TD
Trey McBride
Points+6
Yard line
SF 1
Score
12-13
(8:42) 1-K.Murray pass short right to 85-T.McBride for 1 yard, TOUCHDOWN.
ARIArizona Cardinals
Q4 8:37XP
Chad Ryland
Points+1
Yard line
SF 15
Score
13-13
38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
ARIArizona Cardinals
Q4 3:26Safety
Marcus Jones
Points+2
Yard line
ARI 94
Score
15-13
(3:26) (Shotgun) 10-M.Jones sacked at SF 6 for 0 yards (2-Ma.Wilson). PENALTY on SF-77-D.Puni, Offensive Holding, 6 yards, enforced in End Zone, SAFETY - No Play.
SFSan Francisco 49ers
Q4 0:04FG
Eddy Pineiro
Points+3
Yard line
ARI 17
Score
15-16
(:04) 18-E.Pineiro 35 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
SFSan Francisco 49ers
Q4 0:00FG
Points+3
Yard line
—
Score
15-16
END GAME

Stars of the game

Top performers by total expected points added (EPA).

1Kenneth Murray, Jr. · Arizona Cardinals · Passing · +5.96 total EPA · 41 snaps · +0.15 EPA/play
2Ricky Pearsall · San Francisco 49ers · Receiving · +4.04 total EPA · 11 snaps · +0.37 EPA/play
3Mi. Wilson · Arizona Cardinals · Receiving · +2.43 total EPA · 2 snaps · +1.21 EPA/play
4Zay Jones · Arizona Cardinals · Receiving · +1.90 total EPA · 3 snaps · +0.63 EPA/play
5Malik Harrison · Arizona Cardinals · Receiving · +1.89 total EPA · 6 snaps · +0.32 EPA/play
6Brian Robinson · San Francisco 49ers · Rushing · +1.12 total EPA · 2 snaps · +0.56 EPA/play
7Elijah Higgins · Arizona Cardinals · Receiving · +1.05 total EPA · 1 snaps · +1.05 EPA/play
8Kyle Juszczyk · San Francisco 49ers · Receiving · +0.82 total EPA · 1 snaps · +0.82 EPA/play

FantasyHQ Game MVP

Highest total EPA with the player's top snap and the game's biggest single play when different.

FantasyHQ Game MVP

Kenneth Murray, Jr. — ARI · Passing

Kenneth Murray, Jr. posted the highest total EPA (+5.96) in the game, the strongest overall impact for Arizona Cardinals. Across 41 counted snaps, they averaged +0.15 EPA per play.

Kenneth Murray, Jr.'s top snap (+3.69 EPA): (9:29) (Shotgun) 1-K.Murray pass incomplete deep left to 18-M.Harrison. PENALTY on SF-0-R.Green, Defensive Pass Interference, 33 yards, enforced at SF 34 - No Play.

Biggest single play (+4.65 EPA): Marcus Jones — (12:06) (Shotgun) 10-M.Jones pass deep right to 1-R.Pearsall pushed ob at ARI 6 for 34 yards (13-K.Clark).

Quarterback report card

Marcus Jones led all passers in efficiency for San Francisco 49ers, setting the tone in the passing game according to FantasyHQ analytics.

Marcus Jones (San Francisco 49ers) · 44 dropbacks · 61.4% completion · +3.3% CPOE · -0.02 EPA/play · -0.84 total EPA
Kenneth Murray, Jr. (Arizona Cardinals) · 41 dropbacks · 53.7% completion · -2.6% CPOE · +0.15 EPA/play · +5.96 total EPA

Team stats comparison

Side-by-side offensive and defensive efficiency.

Stat	Arizona Cardinals	San Francisco 49ers
Offensive EPA/play	-0.003	-0.022
Offensive success rate	42.9%	55.8%
Pass EPA/play	+0.145	-0.019
Rush EPA/play	-0.119	-0.258
Defensive EPA/play	+0.022	+0.003
Defensive success rate	44.2%	57.1%

Drive & efficiency notes

Both offenses finished within striking distance on EPA per play (Arizona Cardinals -0.00, San Francisco 49ers -0.02) — a true toss-up on the analytics sheet.

Season benchmark context (offensive EPA per play):

Arizona Cardinals: -0.00 EPA/play (45th percentile vs. 2025 team-game averages)
San Francisco 49ers: -0.02 EPA/play (41st percentile vs. 2025 team-game averages)

Arizona Cardinals: 10 drives, -0.23 total EPA, 3 scoring drives
San Francisco 49ers: 10 drives, -1.72 total EPA, 5 scoring drives

Who scored touchdowns and field goals

Every touchdown and field goal from official play-by-play.

Touchdowns

San Francisco 49ers — Kyle Juszczyk (Marcus Jones pass) (Q4 10:54)
Arizona Cardinals — Trey McBride (Kenneth Murray, Jr. pass) (Q4 8:42)

Field goals

Arizona Cardinals — Chad Ryland (Q2 8:48)
San Francisco 49ers — Eddy Pineiro (Q2 4:26)
San Francisco 49ers — Eddy Pineiro (Q2 0:20)
San Francisco 49ers — Eddy Pineiro (Q2 0:17)
Arizona Cardinals — Chad Ryland (Q3 6:40)
San Francisco 49ers — Eddy Pineiro (Q4 0:04)
San Francisco 49ers — unlisted player (Q4 0:00)

Quarter by quarter

Quarter-by-quarter recap from live scoring plays.

The second quarter: San Francisco 49ers won the period 9–3. Arizona Cardinals connected on a field goal from the SF 16 (Q2 8:48) — (8:48) 38-C.Ryland 34 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.; San Francisco 49ers connected on a field goal from the ARI 19 (Q2 4:26) — (4:26) 18-E.Pineiro 38 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers connected on a field goal from the ARI 33 (Q2 0:20) — (:20) 18-E.Pineiro 51 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers connected on a field goal from the SF 35 (Q2 0:17) — 18-E.Pineiro kicks 61 yards from SF 35 to ARI 4. 4-G.Dortch to ARI 37 for 33 yards (27-J.Brown)..

The third quarter: Arizona Cardinals won the period 3–0. Arizona Cardinals connected on a field goal from the SF 9 (Q3 6:40) — (6:40) 38-C.Ryland 28 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin..

The fourth quarter: San Francisco 49ers won the period 13–9. San Francisco 49ers found the end zone from the ARI 1 (Q4 10:54) — (10:54) 10-M.Jones pass short left to 44-K.Juszczyk for 1 yard, TOUCHDOWN [5-B.Browning].; San Francisco 49ers added 1 points from the ARI 15 (Q4 10:50) — 18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; Arizona Cardinals found the end zone from the SF 1 (Q4 8:42) — (8:42) 1-K.Murray pass short right to 85-T.McBride for 1 yard, TOUCHDOWN.; Arizona Cardinals added 1 points from the SF 15 (Q4 8:37) — 38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.; Arizona Cardinals registered a safety from the ARI 94 (Q4 3:26); San Francisco 49ers connected on a field goal from the ARI 17 (Q4 0:04) — (:04) 18-E.Pineiro 35 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.; San Francisco 49ers connected on a field goal (Q4 0:00) — END GAME.

Turning points

Plays that moved win probability the most.

San Francisco 49ers (Q4 0:04) — (:04) 18-E.Pineiro 35 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead. [WPA +42.6% · EPA +0.26]
San Francisco 49ers (Q4 3:26) — (3:26) (Shotgun) 10-M.Jones sacked at SF 6 for 0 yards (2-Ma.Wilson). PENALTY on SF-77-D.Puni, Offensive Holding, 6 yards, enforced in End Zone, SAFETY - No Play. [WPA -22.6% · EPA -1.72]
Arizona Cardinals (Q4 1:54) — (1:54) 12-B.Gillikin punts 50 yards to end zone, Center-46-A.Brewer, Touchback. [WPA -21.8% · EPA -0.73]
Arizona Cardinals (Q4 9:29) — (9:29) (Shotgun) 1-K.Murray pass incomplete deep left to 18-M.Harrison. PENALTY on SF-0-R.Green, Defensive Pass Interference, 33 yards, enforced at SF 34 - No Play. [WPA +19.2% · EPA +3.69]
San Francisco 49ers (Q4 12:06) — (12:06) (Shotgun) 10-M.Jones pass deep right to 1-R.Pearsall pushed ob at ARI 6 for 34 yards (13-K.Clark). [WPA +17.2% · EPA +4.65]

Impact plays

Highest EPA snaps that flipped field position.

San Francisco 49ers (Q4 12:06) — (12:06) (Shotgun) 10-M.Jones pass deep right to 1-R.Pearsall pushed ob at ARI 6 for 34 yards (13-K.Clark). [WPA +17.2% · EPA +4.65]
San Francisco 49ers (Q4 5:19) — (5:19) (Shotgun) 10-M.Jones pass short right intended for 1-R.Pearsall INTERCEPTED by 42-D.Taylor-Demerson at ARI 21. 42-D.Taylor-Demerson to ARI 39 for 18 yards (71-T.Williams). [WPA -12.6% · EPA -4.17]
San Francisco 49ers (Q3 0:20) — (:20) (Shotgun) 10-M.Jones pass incomplete short left to 23-C.McCaffrey (2-Ma.Wilson). [WPA -11.9% · EPA -3.92]
Arizona Cardinals (Q4 9:29) — (9:29) (Shotgun) 1-K.Murray pass incomplete deep left to 18-M.Harrison. PENALTY on SF-0-R.Green, Defensive Pass Interference, 33 yards, enforced at SF 34 - No Play. [WPA +19.2% · EPA +3.69]

Every scoring play

Chronological scoring with play-by-play context.

Arizona Cardinals FG (+3) — Q2 8:48 · SF 16 · Score 3-0
(8:48) 38-C.Ryland 34 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
San Francisco 49ers FG (+3) — Q2 4:26 · ARI 19 · Score 3-3
(4:26) 18-E.Pineiro 38 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
San Francisco 49ers FG (+3) — Q2 0:20 · ARI 33 · Score 3-6
(:20) 18-E.Pineiro 51 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
San Francisco 49ers FG (+3) — Q2 0:17 · SF 35 · Score 3-6
18-E.Pineiro kicks 61 yards from SF 35 to ARI 4. 4-G.Dortch to ARI 37 for 33 yards (27-J.Brown).
Arizona Cardinals FG (+3) — Q3 6:40 · SF 9 · Score 6-6
(6:40) 38-C.Ryland 28 yard field goal is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
San Francisco 49ers TD (+6) — Q4 10:54 · ARI 1 · Score 6-12
(10:54) 10-M.Jones pass short left to 44-K.Juszczyk for 1 yard, TOUCHDOWN [5-B.Browning].
San Francisco 49ers XP (+1) — Q4 10:50 · ARI 15 · Score 6-13
18-E.Pineiro extra point is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
Arizona Cardinals TD (+6) — Q4 8:42 · SF 1 · Score 12-13
(8:42) 1-K.Murray pass short right to 85-T.McBride for 1 yard, TOUCHDOWN.
Arizona Cardinals XP (+1) — Q4 8:37 · SF 15 · Score 13-13
38-C.Ryland extra point is GOOD, Center-46-A.Brewer, Holder-12-B.Gillikin.
Arizona Cardinals Safety (+2) — Q4 3:26 · ARI 94 · Score 15-13
(3:26) (Shotgun) 10-M.Jones sacked at SF 6 for 0 yards (2-Ma.Wilson). PENALTY on SF-77-D.Puni, Offensive Holding, 6 yards, enforced in End Zone, SAFETY - No Play.
San Francisco 49ers FG (+3) — Q4 0:04 · ARI 17 · Score 15-16
(:04) 18-E.Pineiro 35 yard field goal is GOOD, Center-46-J.Weeks, Holder-7-T.Morstead.
San Francisco 49ers FG (+3) — Q4 0:00 · Score 15-16
END GAME

Key takeaways

What to remember for fantasy research and follow-up box score digging.

San Francisco 49ers earned the result — use the box score for snap-level context.
One-score margin — verify garbage-time stats before drawing fantasy conclusions.
Kenneth Murray, Jr. (Arizona Cardinals) led total EPA — start here for highlight and prop research.
Marcus Jones (SF) finished above expected through the air (positive CPOE).

Frequently asked questions

Who won Arizona Cardinals vs San Francisco 49ers on 2025-09-21?

The San Francisco 49ers beat the Arizona Cardinals 16-15 in Week 3, 2025.

What was the score by quarter in Arizona Cardinals vs San Francisco 49ers?

Q2: Arizona Cardinals 3, San Francisco 49ers 9; Q3: Arizona Cardinals 3, San Francisco 49ers 0; Q4: Arizona Cardinals 9, San Francisco 49ers 13; Final: Arizona Cardinals 15, San Francisco 49ers 16.

Who scored touchdowns and field goals in Arizona Cardinals vs San Francisco 49ers?

San Francisco 49ers touchdown — K. Juszczyk (M. Jones pass) (Q4 10:54) Arizona Cardinals touchdown — T. McBride (K. Murray pass) (Q4 8:42) Arizona Cardinals field goal — C. Ryland (Q2 8:48, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q2 4:26, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q2 0:20, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q2 0:17, 3 pts) Arizona Cardinals field goal — C. Ryland (Q3 6:40, 3 pts) San Francisco 49ers field goal — E. Pineiro (Q4 0:04, 3 pts) San Francisco 49ers field goal — unlisted player (Q4 0:00, 3 pts) Extra points followed each touchdown unless noted in the play-by-play.

How did the quarterbacks play in Arizona Cardinals vs San Francisco 49ers?

Marcus Jones (San Francisco 49ers), 61.4% completion, +3.3% CPOE, -0.02 EPA per dropback, -0.84 total passing EPA. Kenneth Murray, Jr. (Arizona Cardinals), 53.7% completion, -2.6% CPOE, +0.15 EPA per dropback, +5.96 total passing EPA.

Who was FantasyHQ's player of the game in Arizona Cardinals vs San Francisco 49ers?

Kenneth Murray, Jr. (Arizona Cardinals) was FantasyHQ's Game MVP with +5.96 total EPA on Passing plays. across 41 snaps. Their top snap (+3.69 EPA): (9:29) (Shotgun) 1-K.Murray pass incomplete deep left to 18-M.Harrison. PENALTY on SF-0-R.Green, Defensive Pass Interference, 33 yards, enforced at SF 34 - No Play..

Was Arizona Cardinals vs San Francisco 49ers a close game?

Yes — the margin was 1 points. San Francisco 49ers won 16-15 in a game that came down to the wire.

Season records after this game

Arizona Cardinals

Entered 2-0 Now 2-1 L

San Francisco 49ers

Entered 2-0 Now 3-0 W

Arizona Cardinals vs. San Francisco 49ers: 2025 Week 3 Recap

Top fantasy performers · Cardinals

Top fantasy performers · 49ers

Quick answer

Game summary