Isaac Guerendo was drafted No. 129 overall by the San Francisco 49ers in the 2024 NFL Draft out of Louisville. 30 regular-season games · 4 career approximate value
2024 NFL Draft · Rd 4, Pick 29 · #129 overall
Isaac Guerendo Louisville Draft
Isaac Guerendo was drafted No. 129 overall by the San Francisco 49ers in the 2024 NFL Draft out of Louisville. 30 regular-season games · 4 career approximate value
- Overall pick
- #129
- Round
- 4
- Draft class
- 2024
- NFL games
- 30
- Career AV
- 452nd at Louisville
The pick
How Isaac Guerendo came off the board in 2024.
- Position
- Running back RB
- College
-
Louisville
ACC at the draft
- Measurables
- 6'0" · 221 lbs
- Hometown
- Clayton, IN
- Pre-draft board
- No. 146 prospect61.0 grade
- Side of the ball
- Offense
NFL career
30 regular-season games · 4 career approximate value
- Games played
- 30
- Career approximate value
- 452nd among Louisville picks
- AV with the drafting club
- 4100% of career value
- Final season
- 20251 years after the draft
Around pick 129
Who came off the board on either side of Isaac Guerendo.
Clemson
Kentucky · 1× All-Pro
Iowa State
TCU
Louisville in the 2024 draft
Teammates who went in the same class.
Other RB picks from Louisville
The program's most accomplished players at the same spot.
About this draft profile
Last updated Aug 24, 2026
Isaac Guerendo in the 2024 NFL Draft
Isaac Guerendo is a Running back out of Louisville selected No. 129 overall by the San Francisco 49ers in the 2024 NFL Draft. 30 regular-season games · 4 career approximate value Louisville has produced 95 NFL draft picks since 1980.
Where this data comes from
Pick order and career outcomes come from the nflverse draft archive; position, measurables, and conference at the time of the draft come from the college feed. Career columns stay empty until a player logs regular-season snaps.
Frequently asked questions
Where was Isaac Guerendo drafted?
Isaac Guerendo was selected No. 129 overall by the San Francisco 49ers in the 2024 NFL Draft (Rd 4, Pick 29). Full pick detail at https://fantasyhq.co/cfb-hq/draft-history/players/2024/isaac-guerendo.
What college did Isaac Guerendo play for?
Isaac Guerendo played college football at Louisville in the ACC. See every Louisville draft pick at https://fantasyhq.co/cfb-hq/draft-history/schools/louisville-cardinals.
How did Isaac Guerendo's NFL career turn out?
30 regular-season games · 4 career approximate value Career outcome data at https://fantasyhq.co/cfb-hq/draft-history/players/2024/isaac-guerendo.