Marquiss Spencer was drafted No. 253 overall by the Denver Broncos in the 2021 NFL Draft out of Mississippi State. 1 regular-season games
2021 NFL Draft · Rd 7, Pick 26 · #253 overall
Marquiss Spencer Mississippi State Draft
Marquiss Spencer was drafted No. 253 overall by the Denver Broncos in the 2021 NFL Draft out of Mississippi State. 1 regular-season games
- Overall pick
- #253
- Round
- 7
- Draft class
- 2021
- NFL games
- 1
The pick
How Marquiss Spencer came off the board in 2021.
- Position
- Defensive end DE
- Measurables
- 6'4" · 301 lbs
- Hometown
- Greenwood, MS
- Pre-draft board
- No. 316 prospect30.0 grade
- Side of the ball
- Defense
NFL career
1 regular-season games
- Games played
- 1
- Final season
- 20210 years after the draft
Around pick 253
Who came off the board on either side of Marquiss Spencer.
BYU
Concordia St. Paul
Georgia Tech
South Alabama
Mississippi State in the 2021 draft
Teammates who went in the same class.
Other DE picks from Mississippi State
The program's most accomplished players at the same spot.
Montez Sweat
DE · WAS · 2019
Mississippi State · 1× Pro Bowl
#38
Preston Smith
DE · WAS · 2015
Mississippi State
#108
Kevin Henry
DE · PIT · 1993
Mississippi State
#165
Pernell McPhee
DE · BAL · 2011
Mississippi State
#120
Alvin McKinley
DE · CAR · 2000
Mississippi State
#116
Robert Young
DE · LAR · 1991
Mississippi State
About this draft profile
Last updated Aug 24, 2026
Marquiss Spencer in the 2021 NFL Draft
Marquiss Spencer is a Defensive end out of Mississippi State selected No. 253 overall by the Denver Broncos in the 2021 NFL Draft. 1 regular-season games Mississippi State has produced 113 NFL draft picks since 1980.
Where this data comes from
Pick order and career outcomes come from the nflverse draft archive; position, measurables, and conference at the time of the draft come from the college feed. Career columns stay empty until a player logs regular-season snaps.
Frequently asked questions
Where was Marquiss Spencer drafted?
Marquiss Spencer was selected No. 253 overall by the Denver Broncos in the 2021 NFL Draft (Rd 7, Pick 26). Full pick detail at https://fantasyhq.co/cfb-hq/draft-history/players/2021/marquiss-spencer.
What college did Marquiss Spencer play for?
Marquiss Spencer played college football at Mississippi State in the SEC. See every Mississippi State draft pick at https://fantasyhq.co/cfb-hq/draft-history/schools/mississippi-state-bulldogs.
How did Marquiss Spencer's NFL career turn out?
1 regular-season games Career outcome data at https://fantasyhq.co/cfb-hq/draft-history/players/2021/marquiss-spencer.