PITTSBURGH PANTHERS
PITT
8-5
39% win
Upcoming
LOU favored · LOU -1.9
LOUISVILLE CARDINALS
LOU
9-4
61% win
Win probability
SP+ model
PITT 39%
LOU 61%
Pick: LOU
LOU -1.9
O/U 56.0
- Record
- 8-5
- SP+
-
+8.4
- SP+ Off
- 31.6
- SP+ Def
- -23.5
- Record
- 9-4
- SP+
-
+12.4
- SP+ Off
- 31.6
- SP+ Def
- -19.8
Recent head-to-head
PITT 4–4 LOU
2025
Wk 5
Wk 5
LOU
W
34
FINAL
27
PITT
2024
Wk 13
Wk 13
PITT
9
FINAL
37
W
LOU
2023
Wk 7
Wk 7
LOU
21
FINAL
38
W
PITT
2022
Wk 8
Wk 8
PITT
10
FINAL
24
W
LOU
2020
Wk 4
Wk 4
LOU
20
FINAL
23
W
PITT
2015
Wk 12
Wk 12
LOU
34
FINAL
45
W
PITT
2012
Wk 7
Wk 7
LOU
W
45
FINAL
35
PITT
2011
Wk 11
Wk 11
PITT
W
21
FINAL
14
LOU
Recent form
Pittsburgh Panthers
vs MIA
@ GT
vs ND
@ STAN
vs NCSU
Louisville Cardinals
vs UK
@ SMU
vs CLEM
vs CAL
@ VT
Panthers vs Cardinals — FAQ
Who wins Panthers vs Cardinals?
FantasyHQ's SP+ model projects Louisville at 61% to win (26.1–29.9) for 2026 CFB Week 12.
What is the Panthers vs Cardinals predicted score?
Projected score: PITT 26.1 – LOU 29.9. Spread model: LOU -1.9; total: O/U 56.0.
When is the Panthers vs Cardinals game?
Pittsburgh Panthers face Louisville Cardinals in 2026 CFB Week 12 on Sat, Nov 21 at 12:00 AM ET. Venue: L&N Federal Credit Union Stadium.