LOUISVILLE CARDINALS
LOU
9-4
55% win
Final
34 – 27
PITTSBURGH PANTHERS
PITT
8-5
45% win
Win probability
SP+ model
LOU 55%
PITT 45%
Pick: LOU
LOU -0.4
O/U 56.0
- Record
- 9-4
- SP+
-
+12.4
- SP+ Off
- 31.6
- SP+ Def
- -19.8
- Record
- 8-5
- SP+
-
+8.4
- SP+ Off
- 31.6
- SP+ Def
- -23.5
Recent head-to-head
LOU 3–5 PITT
2024
Wk 13
Wk 13
PITT
9
FINAL
37
W
LOU
2023
Wk 7
Wk 7
LOU
21
FINAL
38
W
PITT
2022
Wk 8
Wk 8
PITT
10
FINAL
24
W
LOU
2020
Wk 4
Wk 4
LOU
20
FINAL
23
W
PITT
2015
Wk 12
Wk 12
LOU
34
FINAL
45
W
PITT
2012
Wk 7
Wk 7
LOU
W
45
FINAL
35
PITT
2011
Wk 11
Wk 11
PITT
W
21
FINAL
14
LOU
2010
Wk 9
Wk 9
LOU
3
FINAL
20
W
PITT
Recent form
Louisville Cardinals
vs UK
@ SMU
vs CLEM
vs CAL
@ VT
Pittsburgh Panthers
vs MIA
@ GT
vs ND
@ STAN
vs NCSU
Cardinals vs Panthers — FAQ
Who wins Cardinals vs Panthers?
FantasyHQ's SP+ model projects Louisville at 55% to win (28.4–27.6) for 2025 CFB Week 5.
What is the Cardinals vs Panthers predicted score?
Projected score: LOU 28.4 – PITT 27.6. Spread model: LOU -0.4; total: O/U 56.0.
When is the Cardinals vs Panthers game?
Louisville Cardinals face Pittsburgh Panthers in 2025 CFB Week 5 on Sat, Sep 27 at 12:00 PM ET. Venue: Acrisure Stadium.