Santonio Holmes was drafted No. 25 overall by the Pittsburgh Steelers in the 2006 NFL Draft out of Ohio State. 112 regular-season games · 6 seasons as a starter · 47 career approximate value
2006 NFL Draft · Rd 1, Pick 25 · #25 overall
Santonio Holmes Ohio State Draft
Santonio Holmes was drafted No. 25 overall by the Pittsburgh Steelers in the 2006 NFL Draft out of Ohio State. 112 regular-season games · 6 seasons as a starter · 47 career approximate value
- Overall pick
- #25
- Round
- 1
- Draft class
- 2006
- NFL games
- 112
- Years as starter
- 6
- Career AV
- 4737th at Ohio State
The pick
How Santonio Holmes came off the board in 2006.
- Position
- Wide receiver WR
- College
-
Ohio State
Big Ten at the draft
- Measurables
- 5'11" · 188 lbs
- Pre-draft board
- No. 16 prospect95.0 grade
- Side of the ball
- Offense
NFL career
112 regular-season games · 6 seasons as a starter · 47 career approximate value
- Games played
- 112
- Seasons as a starter
- 6
- Career approximate value
- 4737th among Ohio State picks
- AV with the drafting club
- 3574% of career value
- Final season
- 20148 years after the draft
Around pick 25
Who came off the board on either side of Santonio Holmes.
Oklahoma · 2× Pro Bowl
South Carolina · 2× Pro Bowl
NC State
Memphis · 1× Pro Bowl
Ohio State in the 2006 draft
Teammates who went in the same class.
A.J. Hawk
LB · GB
Ohio State · 1× Pro Bowl
#8
Donte Whitner
DB · BUF
Ohio State · 2× Pro Bowl
#18
Bobby Carpenter
LB · DAL
Ohio State
#29
Nick Mangold
C · NYJ
Ohio State · 2× All-Pro · 7× Pro Bowl
#70
Ashton Youboty
DB · BUF
Ohio State
#76
Anthony Schlegel
LB · NYJ
Ohio State
#121
Nate Salley
DB · CAR
Ohio State
#128
Rob Sims
G · SEA
Ohio State
Other WR picks from Ohio State
The program's most accomplished players at the same spot.
Michael Thomas
WR · NO · 2016
Ohio State · 2× All-Pro · 3× Pro Bowl
#76
Terry McLaurin
WR · WAS · 2019
Ohio State · 2× Pro Bowl
#20
Jaxon Smith-Njigba
WR · SEA · 2023
Ohio State · 1× All-Pro · 2× Pro Bowl
#7
Terry Glenn
WR · NE · 1996
Ohio State · 1× Pro Bowl
#8
David Boston
WR · ARI · 1999
Ohio State · 1× All-Pro · 1× Pro Bowl
#8
Joey Galloway
WR · SEA · 1995
Ohio State
About this draft profile
Last updated Aug 24, 2026
Santonio Holmes in the 2006 NFL Draft
Santonio Holmes is a Wide receiver out of Ohio State selected No. 25 overall by the Pittsburgh Steelers in the 2006 NFL Draft. 112 regular-season games · 6 seasons as a starter · 47 career approximate value Ohio State has produced 284 NFL draft picks since 1980.
Where this data comes from
Pick order and career outcomes come from the nflverse draft archive; position, measurables, and conference at the time of the draft come from the college feed. Career columns stay empty until a player logs regular-season snaps.
Frequently asked questions
Where was Santonio Holmes drafted?
Santonio Holmes was selected No. 25 overall by the Pittsburgh Steelers in the 2006 NFL Draft (Rd 1, Pick 25). Full pick detail at https://fantasyhq.co/cfb-hq/draft-history/players/2006/santonio-holmes.
What college did Santonio Holmes play for?
Santonio Holmes played college football at Ohio State in the Big Ten. See every Ohio State draft pick at https://fantasyhq.co/cfb-hq/draft-history/schools/ohio-state-buckeyes.
How did Santonio Holmes's NFL career turn out?
112 regular-season games · 6 seasons as a starter · 47 career approximate value Career outcome data at https://fantasyhq.co/cfb-hq/draft-history/players/2006/santonio-holmes.